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Wt p53 function is regulated bycomplex combinations of post-translational modi?cations including phosphoryla-tion, acetylation, ubiquitination, methylation, sumoylation and neddylation [ 24 ].On the contrary, we know very little about the post-translational modi? cations pres-ent in mutant p53 and the enzymes responsible for them. 1986) and throughout childhood(McCormick et al

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